Platelet Rich Plasma in East Paris
Aesthetic Medicine Pr Meningaud
What is PRP?
PRP is widely used in aesthetic medicine in Asia. Numerous studies have demonstrated the role of autologous PRP preparations, obtained from the patient’s own blood, in the healing of soft [1], [2] and hard [3] tissues.
In wound treatment, the use of PRP has been shown to lead to more rapid regeneration of damaged tissue, as well as a reduction in inflammation and pain.
The mechanism is linked to the release of growth factors by platelets. These factors act locally and are essential for cell differentiation and the regeneration of new tissue.
Attempts to use isolated growth factors have proved unsuccessful due to the inability of a single growth factor to regulate the entire regeneration process. What’s more, they are much more expensive to produce.
Platelet Rich Plasma (PRP) at Paris Est
Professor Meningaud at Henri-Mondor
Autologous PRP
In contrast, autologous PRP represents an economically viable, safe and effective approach. It is based on the progressive release at the site of administration of an appropriate cocktail of growth factors. The relative proportions of these factors are natural and physiological.
Autologous PRP has been used safely in many disciplines, including dentistry, maxillofacial surgery, plastic and reconstructive surgery, orthopaedic surgery, cardiovascular surgery and the treatment of acute and chronic wounds.
It can be used on its own, or to enrich other cellular preparations such as fat injections, which have radically changed the plastic surgery paradigm. PRP is used in aesthetic medicine in many countries. In France, scientific studies in which we are participating are underway[4].
In the aesthetic field, we have so far only used them in the context of official institutional research.
We routinely use these techniques in medical and reconstructive surgery, using devices validated by the APHP pharmacy.
[1] Barbara Hersant, Mounia Sid-Ahmed, Laura Braud, Maud Jourdan, Yasmine Baba-Amer, Jean-Paul Meningaud, Anne-Marie Rodriguez. Platelet-Rich Plasma Improves the Wound Healing Potential of Mesenchymal Stem Cells through Paracrine and Metabolism Alterations. Stem Cells Int. 2019;2019:1234263.
[2] Tsai HC et al. Use of platelet-rich plasma and platelet-derived patches to treat chronic wounds. J Wound Care. 2019;28(1):15-21.
[3] Tabrizi R et al. Does platelet-rich plasma enhance healing in the idiopathic bone cavity? A single-blind randomised clinical trial. Int J Oral Maxillofac Surg. 2015;44(9):1175-1180.
[4] Barbara Hersant, Mounia SidAhmed-Mezi, Jeremy Niddam, Simone La Padula, Warren Noel, Khaled Ezzedine, Anne Marie Rodriguez, Jean Paul Meningaud. Efficacy of autologous platelet-rich plasma combined with hyaluronic acid on skin facial rejuvenation: A prospective study. J Am Acad Dermatol. 2017;77(3):584-586.